Development of reinforced polylactide composite resin for micro surgery bone plate and screw

Joon Woo Chon; In Kyu Jang; Seung Woo Suh; In Kwon Chung; Sung Min Chung; Dong June Chung

Macromolecular Research, Vol.24, No.1, 37-43, January, 2016

DOI10.1007/s13233-016-4003-y Export Citation

Development of reinforced polylactide composite resin for micro surgery bone plate and screw

Joon Woo Chon, In Kyu Jang¹, Seung Woo Suh¹, In Kwon Chung¹, Sung Min Chung¹, and Dong June Chung^†

Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon, Gyeonggi, 16419, Korea
¹Genoss Co, Ltd, Gyeonggi R&DB Center, 105 Gwanggyo-ro, Yeongtong-gu, Suwon, Gyeonggi, 16229, Korea

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In this study, composites of polylactide (PLA) and hyaluronic acid-chitosan ionic complex (HACS) which are derived from hyaluronic acid (HA) and chitosan (CS), respectively, were prepared to investigate the enhancing effects of their mechanical properties, crystallinity, and biodegradation. To reach reasonable tensile modulus properties such as those in human bone, β-tricalcium phosphate (BCP) was added, which can prevent the stress shielding effect. The addition of reinforcements in the PLA matrix significantly increased the tensile strength and modulus of the PLA composites. To verify the effect of reinforcements on crystallinity behavior and surface morphology, we used differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) to examine dispersion properties. Moreover, an in vitro enzymatic biodegradation test on composites was carried out with esterase from porcine liver at 37 °C in PBS solution (pH 7.4).

Keywords:polylactide;hyaluronic acid;chitosan;β-tricalcium phosphate;reinforcement

[References]

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Nair LS, Laurencin CT, Prog. Polym. Sci, 32, 11 (2007)
Auras R, Harte B, Selke S, Macromol. Biosci., 4, 11 (2004)
Hiljanen-Vainio M, Varpomaa P, Seppala J, Tormala P, Macromol. Chem. Phys., 197, 11 (1996)
Grijpma DW, Nijenhuis AJ, Van Wijk PGT, Pennings AJ, Polym. Bull., 29, 11 (1992)
Mascia L, Xanthos M, Adv. Polym. Technol., 11, 11 (1992)
Avella M, Bogoeva-Gaceva G, Buzarovska A, Errico ME, Gentile G, Grozdanov A, J. Appl. Polym. Sci., 108, 11 (2008)
Huda MS, Drzal LT, Misra M, Mohanty AK, J. Appl. Polym. Sci., 102, 11 (2006)
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Xiao Y, Li D, Fan H, Li X, Gu Z, Zhang X, Mater. Lett., 61, 11 (2007)
Palumbo FS, Pitarresi G, Mandracchia D, Tripodo G, Giammona G, Carbohydr. Polym., 66, 11 (2006)
Martino AD, Sittinger M, Risbud MV, Biomaterials, 26, 11 (2005)
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Kasuga T, Fujikawa H, Abe Y, J. Mater. Res., 14, 11 (1999)
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Ogata N, Jimenez G, Kawai H, Ogihara T, J. Polym. Sci. B: Polym. Phys., 35, 11 (1997)
Reeve MS, McCarthy SP, Downey MJ, Gross RA, Macromolecules, 27, 11 (1994)
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Cheung HY, Lau KT, Pow YF, Zhao YQ, Hui D, Compos. Pt. B-Eng., 41, 11 (2010)
Jordan J, Jacob KI, Tannenbaum R, Sharaf MA, Jasiuk I, Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process., 393, 11 (2005)
Shah BL, Selke SE, Walters MB, Heiden PA, Polym. Compos., 29, 11 (2008)
Ogilvie A, Frank RM, Benque EP, Gineste M, Heughebaert M, Hemmerie J, J. Periodontal Res., 22, 11 (1987)
Mantia FPL, Morreale M, Compos. Pt. A-Appl. Sci. Manuf., 42, 11 (2011)
Diao H, Si Y, Zhu A, Ji L, Shi H, Mater. Sci. Eng. C-Mater. Biol. Appl., 32, 11 (2012)
Liao R, Tang B, Yu W, Zhou C, J. Appl. Polym. Sci., 104, 11 (2007)

[Referenced By]

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[1] Lim LT, Auras R, Rubio M, Prog. Polym. Sci, 33, 11 (2008)

[2] Nair LS, Laurencin CT, Prog. Polym. Sci, 32, 11 (2007)

[3] Auras R, Harte B, Selke S, Macromol. Biosci., 4, 11 (2004)

[4] Hiljanen-Vainio M, Varpomaa P, Seppala J, Tormala P, Macromol. Chem. Phys., 197, 11 (1996)

[5] Grijpma DW, Nijenhuis AJ, Van Wijk PGT, Pennings AJ, Polym. Bull., 29, 11 (1992)

[6] Mascia L, Xanthos M, Adv. Polym. Technol., 11, 11 (1992)

[7] Avella M, Bogoeva-Gaceva G, Buzarovska A, Errico ME, Gentile G, Grozdanov A, J. Appl. Polym. Sci., 108, 11 (2008)

[8] Huda MS, Drzal LT, Misra M, Mohanty AK, J. Appl. Polym. Sci., 102, 11 (2006)

[9] Rasal RM, Janorkar AV, Hirt DE, Prog. Polym. Sci, 35, 11 (2010)

[10] Pei A, Zhou Q, Berglund LA, Compos. Sci. Technol., 70, 11 (2010)

[11] Xiao Y, Li D, Fan H, Li X, Gu Z, Zhang X, Mater. Lett., 61, 11 (2007)

[12] Palumbo FS, Pitarresi G, Mandracchia D, Tripodo G, Giammona G, Carbohydr. Polym., 66, 11 (2006)

[13] Martino AD, Sittinger M, Risbud MV, Biomaterials, 26, 11 (2005)

[14] Navarro M, Michiardi A, Castano O, Planell JA, J. R. Soc. Interface, 5, 11 (2008)

[15] Kasuga T, Fujikawa H, Abe Y, J. Mater. Res., 14, 11 (1999)

[16] Nam HS, An JH, Chung DJ, Kim JH, Chung CP, Macromol. Res., 14, 11 (2006)

[17] Nam HS, Chung DJ, KOREAN Patent 10-2004-0041736 (2002).

[18] Ogata N, Jimenez G, Kawai H, Ogihara T, J. Polym. Sci. B: Polym. Phys., 35, 11 (1997)

[19] Reeve MS, McCarthy SP, Downey MJ, Gross RA, Macromolecules, 27, 11 (1994)

[20] Liu CZ, Zhao Y, Wang YC, Appl. Microbiol. Biotechnol., 72(1), 11 (2006)

[21] ASTM D 638, ASTM International, West Conshohocken (2010).

[22] Cheung HY, Lau KT, Pow YF, Zhao YQ, Hui D, Compos. Pt. B-Eng., 41, 11 (2010)

[23] Jordan J, Jacob KI, Tannenbaum R, Sharaf MA, Jasiuk I, Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process., 393, 11 (2005)

[24] Shah BL, Selke SE, Walters MB, Heiden PA, Polym. Compos., 29, 11 (2008)

[25] Ogilvie A, Frank RM, Benque EP, Gineste M, Heughebaert M, Hemmerie J, J. Periodontal Res., 22, 11 (1987)

[26] Mantia FPL, Morreale M, Compos. Pt. A-Appl. Sci. Manuf., 42, 11 (2011)

[27] Diao H, Si Y, Zhu A, Ji L, Shi H, Mater. Sci. Eng. C-Mater. Biol. Appl., 32, 11 (2012)

[28] Liao R, Tang B, Yu W, Zhou C, J. Appl. Polym. Sci., 104, 11 (2007)