Positive displacement compressors lead the market of compressed air production for industrial applications. Among them, sliding vane rotary compressors represent an energetically virtuous alternative to the current compression technologies. In the present work, the effects of compressor design parameters were investigated through a comprehensive approach that aimed at addressing more efficient machines to promote sliding vane compressors as the key enabling technology in compressed air systems. A comprehensive mathematical model was developed to study the main phenomena occurring in this kind of compressors. The model provides the cell volume evolution over a whole rotation during which filling, compression and discharge processes occur. The first and latter phases are described by the quasipropagatory approach that represents the inertial, capacitive and resistive features of one-dimensional unsteady flows. The dynamics of the compressor blades led to four different arrangements inside the rotor slots while an analysis of the hydrodynamic lubrication established between blade tip and stator wall focused on the oil film thickness evolution to prevent dry contacts. An extensive experimental campaign on a mid-size industrial compressor allowed the model validation at different outlet pressure levels and revolution speeds using a direct measurement of mechanical power and the reconstruction of the indicator diagram from piezoelectric pressure transducers. The friction coefficient at the contact points between blades with stator and rotor was estimated in 0.065 and further improvements of the mechanical efficiency were eventually addressed considering the roles of compressor aspect ratio, revolution speed, and blade tilt. The first two theoretical optimizations might lead to an increase of the compressor efficiency of 2 and 9 percentage points respectively. On the other hand, acting on the blade tilt would not produce relevant improvements. (C) 2015 Elsevier Ltd. All rights reserved.