Electrochemical oxidation is an effective method in removal of organic pollutant from high salinity waste-water (NaCl), by producing active chlorine at anode or hydrogen peroxide at cathode. To solve the existing problems including low efficiency, high cost and energy consumption, a Ti/SnO2-Sb anode (TSSA)-air diffusion cathode (TSSA-ADC) system was investigated for methyl orange (MO) removal from NaCl solution, using single TSSA system as control. The phase composition of TSSA was examined by X-ray diffraction. Accumulated concentrations of active chlorine, hydrogen peroxide, MO removal rate, TOC, pH value were recorded at different current densities. The results indicated that Sb-doped rutile SnO2 was formed on the TSSA. The TSSA and the ADC exhibited good catalysis to chlorine evolution and oxygen reduction, respectively. Although MO were almost completely removed in both systems, higher TOC removal, shorter running time and lower energy consumption were attained in the TSSA-ADC system. pH value was more stable (6.0-6.4) in the TSSA-ADC system than that in the TSSA system (6.0-9.4), predicting its stronger capacity in anti-scaling when treating high salinity wastewater with hard ions like Ca2+ and Mg2+. (C) 2015 Elsevier B.V. All rights reserved.