An industrial cyclone separator with helical-roof inlet TsN-11 has been numerically investigated as to pressure and flow field, pressure drop, fractional efficiency, and particle trajectories inside the cyclone. The turbulence was modeled with Reynolds stresses and large eddy simulations (LES) based on three different subgrid-scales (SGS). The results with the different setups were compared to experimental data from previous studies. For a proper calculation of the flow field, LES combined with a dynamic SGS model was used for predicting cyclone performance. Individual particles were tracked through the unsteady flow field using the Lagrangian approach. The results of the numerical calculations of the tangential and axial velocity, pressure drop, and cut size are in good agreement with experimental measurements.