A laboratory-scale fixed-bed adsorption system was used to evaluate the capability of various adsorbents for removing methyl iodide from the acetic acid solution. Ag/Amberlite IR 120, Dowex R W50-X8, as well as a new adsorbent namely Ag/Amberlyst 15 were implemented to evaluate their removal efficiencies. Effect of process parameters such as temperature, flow rate of acetic acid solution, and resin's silver content were investigated. The experimental results indicated that a significant improvement in iodide compound removal efficiency can be achieved by using Ag/Amberlyst 15. The results also showed that the removal efficiency was increased with increasing the temperature as well as the resin's silver content, while the flow rate of acetic acid solution had a negative effect on this efficiency. The maximum removal efficiency was found to be 99% at temperature 24.5 degrees C, flow rate 5.73 BV/h, and with Ag/Amberlyst 15 92% silver impregnated.