Acetaminophen is a common low water-soluble drug whose solubility could be increased using various methods, including addition of a pharmaceutical cosolvent. The solubility of acetaminophen in ethanol+water+NaCl mixtures at 293.2, 298.2, 303.2, 308.2, and 313.2K was determined and the results showed that NaCl addition to the solution decreased the solubility. The generated data were mathematically represented using a modified version of the Jouyban-Acree model within an acceptable accuracy.