The nonlinear frequency response (NFR) method is applied for evaluation of possible improvement through simultaneous periodic modulation of two inputs of a non-isothermal continuously stirred tank reactor (CSTR) in which homogeneous nth order reaction A -> product(s) takes place. The two modulated inputs are the concentration of the reactant in the feed steam and the temperature of the feed stream. The cross asymmetrical second order FRF which correlates the outlet concentration with both modulated inputs is derived and analyzed. The optimal phase difference which should be used in order to maximize the conversion is determined. The method is tested on three numerical examples of non-isothermal CSTRs: (a) one which is oscillatory stable with strong resonant behavior, (b) one which is oscillatory stable with weak resonant behavior and (c) one which is nonoscillatory stable. Good agreement between the results of the approximate NFR method and the results of "exact" numerical integration is obtained except for the reactor with strong resonance for forcing frequencies which are close to the resonant frequency and for the reactor with weak resonant behavior for forcing frequency equal to the resonant one in case of high forcing amplitudes. (C) 2015 Elsevier Ltd. All rights reserved.