화학공학소재연구정보센터
Chemical Engineering Science, Vol.137, 338-351, 2015
Mass-count plots for crystal size control
We present measurements from batch crystallization as a trajectory in the phase space mapped out by the crystal mass and the total chord count. This new perspective yields a framework for monitoring and controlling crystallization that has two beneficial attributes: first, crystallization is seen as movement we find that this fosters an intuitive understanding of crystallization kinetics; and, second, the problem of controlling the average crystal size is cast as a trajectory-endpoint control problem-we find that this promotes the development of spatially-oriented control schemes. The utility of the proposed framework is demonstrated by application. In particular, we apply the framework to: 1) elucidate the effects of simple temperature manipulations on the crystallization kinetics; 2) interpret the actions applied by supersaturation control (SSC) and direct nucleation control (DNC) to produce large crystals; and 3) develop a control scheme-termed spatially-guided action trajectory endpoint control (sGATEC)-that can be applied to produce crystals of pre-selected average size. (C) 2015 Elsevier Ltd. All rights reserved.