A multitude of karstic paleo-cave gas-condensate reservoirs have been discovered in recent years in the Ordovician formation in the Tarim Basin in West China. The maximum gas and condensate recoveries from these reservoirs depend directly on the choice of the development approach. Nine sets of experiments using artificial full-diameter fractured-cavernous cores have been performed to evaluate hydrocarbon recovery under conditions of water flooding and natural depletion. The results suggest that water flooding is more efficient in enhancing condensate recovery. It is found that the overall hydrocarbon recovery by water flooding of a karstic paleo-cave gas-condensate reservoir is higher at higher pressures above dew point, which distinguishes these reservoirs from the usual sandstone gas-condensate reservoirs.