화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Polymer(Korea), Vol.40, No.2, 328-335, March, 2016
DOI10.7317/pk.2016.40.2.328  Export Citation
N-아세틸화 글리콜 키토산의 합성과 온도감응성 졸-젤 전이 특성
Synthesis of N-Acetylated Glycol Chitosans and Their Thermo-sensitive Sol-Gel Transition Properties
유호선1, 1, 2, 조익성1, 이정정1, 3, 김남홍4, 장미경4, 강선웅2, 5, 허강무1, †
  • 1충남대학교 고분자공학과
  • 2안전성평가연구소
  • 3천진과학기술대학교
  • 4순천대학교 고분자공학과
  • 5과학기술연합대학원대학교 인체 및 환경 독성학과
Ho Seon You1, 조명옥1, 2, Ik Sung Cho1, Zhengzheng Li1, 3, Nam-Hong Kim4, Mi-Kyeong Jang4, Sun-Woong Kang2, 5, and Kang Moo Huh1, †
  • 1Dept. Polymer Science and Engineering, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Korea
  • 2Next-generation Pharmaceutical Research center, Korea Institute of Toxicology, Daejeon 34114, Korea
  • 3College of Chemical Engineering and Material Science, Tianjin University of Science & Technology, Tianjin 300-457, China
  • 4Dept. Polymer Science and Engineering, Sunchon National University, 255 Jungangdong, Suncheon, Jeonnam 57922, Korea
  • 5Human and Environmental Toxicology Program, University of Science and Technology, Daejeon 34113, Korea
E-mail:
초록
본 연구에서는 수용성 천연고분자인 글리콜 키토산의 N-아세틸화를 통해 새로운 천연고분자 기반의 온도감응성 고분자를 합성하고, 온도감응성을 평가하였다. 글리콜 키토산의 N-아세틸화 반응을 통해 글리콜 키틴 구조의 고분자를 성공적으로 합성하였고, 수용액 상에서 37 ℃ 주변에서 온도감응성 졸-젤 전이현상이 효과적으로 일어남을 확인하였다. 이러한 졸-젤 전이 특성은 기존의 합성고분자 기반 온도감응성 고분자에 비해 상대적으로 더 낮은 농도(3~16 wt%)에서 보였고, 고분자의 분자량, 아세틸화도, 농도를 변화시킴으로써 효과적으로 조절될 수 있었다. 글리콜 키틴은 우수한 온도감응성 뿐 아니라 낮은 세포독성과 향상된 젤 안정성을 보임으로써, 약물전달, 조직공학, 3차원 세포배양 등 다양한 생체의료용 응용분야에 유용하게 활용될 수 있을 것으로 전망된다.
In this study, new polysaccharide-based thermo-sensitive polymers were synthesized and their thermo-sensitive sol-gel transition properties were evaluated. Glycol chitin structures were successfully introduced by N-acetylation reaction of glycol chitosan. The aqueous solutions of glycol chitins demonstrated unique thermo-sensitive sol-gel transition behaviors around 37 ℃. Their sol-gel transition properties were observed at a relatively lower concentration range (3~16 wt%) compared to those of typical synthetic polymer based systems and efficiently modulated by varying molecular weight, DA, and concentration. Based on their thermo-sensitivity, low cyto-toxicity, and high gel stability, the glycol chitin polymers could be utilized for various biomedical applications, such as drug delivery, tissue engineering, and 3D cell culture.
Keywords:glycol chitosan;N-acetylation;sol-gel transition;thermo-sensitive hydrogel
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