Knowledge of H-2-N2O mixtures explosive properties is important to the safety of nuclear waste storage and semi-conductor manufacturing processes. The present study provides new experimental data on H-2-N2O detonations, and proposes a thermochemical model which is used to numerically simulate detonation propagation. Detonation cell size has been measured in a variety of H-2-N2O-Ar mixtures. Even at low initial pressure, these mixtures are very sensitive to detonation with cell size of few millimeters. Using a reduced version of a detailed reaction scheme, 2-D Euler simulations have been used to examine the features of detonation in H-2-N2O-Diluent mixtures. A PLIF model has been applied to allow for direct comparison with experimental results. Statistical analysis of the cellular cycle dynamics has been performed. (C) 2014 The Combustion Institute. Published by Elsevier Inc. All rights reserved.