Multi-effects evaporation with thermal vapor compression (MEE-TVC) is one of the most effective desalination method in which the TVC plays a main role with consideration of energy consumption. In this paper, the steady-state mathematical model of MEE-TVC based on LINGO algorithm is developed and is examined against commercial desalination plants. The model can be adapted to conventional equal temperature difference design method and equal heat transfer area design method as well because of the generality of the model and the maintainability of the programs. By inducing suction position variable the influence of parameters of TVC including suction position, suction pressure, motive vapor pressure, top brine temperature etc. on the operation of MEE-TVC system is investigated. It is found that the improvement of performance ratio and decreasing energy consumption can be achieved by optimization of integrating TVC suction position with operations of each effect. The end effect is almost the optimal position for TVC expect for some cases in equal temperature difference design situation with regards of the gain output ratio as objective. (C) 2015 Elsevier B.V. All rights reserved.