A photoactive interface is formed between an electrochemical generated organic polymer film and CdSe quantum dots. The specifically designed and synthesized 3,4 ethylenedioxythiophene electroactive monomer, holding C-60 buckminsterfullerene, allows the formation of thin films containing both, electron acceptor and hole transport moieties. The generation of photoinduced heterogeneous charge transfer in CdSe quantum dots-electropolymer system was characterized by time resolved and spectral dependent surface photovoltage. In films containing C-60 moieties whose surface was modified with 5 nm CdSe quantum dots, the illumination generated photovoltage values around twenty times larger than those obtained without nanoparticles decoration. The results show that this organic-inorganic hybrid interface is a potential structure for the development of optoelectronic devices. (C) 2015 Elsevier Ltd. All rights reserved.