The paper describes a study developed to estimate the energy savings potential of a radiant cooling system installed in a commercial building in India. To evaluate thermal performance and energy consumption, simulations were carried out using FLUENT and EnergyPlus software, respectively. The building model was calibrated using the measured data for the installed radiant system. Then this calibrated model was used to simulate the energy consumption of a building using a conventional all-air system to determine the proportional energy savings. For proper handling of the latent load, a Dedicated Outside Air System (DOAS) was used as an alternative to Fan Coil Unit (FCU) that was installed in conjunction with the radiant cooling system. A comparison of energy consumption calculated that the radiant system was 17.5% more efficient than a conventional all-air system and that a 30% savings was achieved by using a DOAS system compared with a conventional system. The Computational Fluid Dynamics (CFD) simulation showed that a radiant system offers more uniform temperatures, as well as a better mean air temperature range, than a conventional system. To further enhance the energy savings in the radiant system, different operational strategies were analyzed based on thermal analysis using EnergyPlus. (C) 2015 Elsevier B.V. All rights reserved.