Computer software, basing on the theoretical model of Huang et al. with thermodynamic properties of selected refrigerants, was prepared. Investigation was focused on alternative refrigerants that belong to two groups of substances: common solvents (acetone, benzene, cyclopentane, cyclohexane and toluene) and non-flammable synthetic refrigerants applied in Organic Rankine Cycle (ORC) (R236ea, R236fa, R245ca, R245fa, R365mfc and RC318). Refrigerants were selected to detect a possibility to use them in ejector cooling system powered by a high-temperature heat source. A series of calculations were carried out for the generator temperature between 70 and 200 degrees C, with assumed temperatures of evaporation 10 degrees C and condensation 40 degrees C. Investigation revealed that there is no single refrigerant that ensures efficient operation of the system in the investigated temperature range of primary vapor. Each substance has its own maximum entrainment ratio and COP at its individual temperature of the optimum. The use of non-flammable synthetic refrigerants allows obtaining higher COP in the low primary vapor temperature range. R236fa was the most beneficial among the non-flammable synthetic refrigerants tested. The use of organic solvents can be justified only for high values of motive steam temperature. Among the solvents, the highest values of entrainment ratio and COP throughout the range of motive temperature were noted for cyclopentane. Toluene was found to be an unattractive refrigerant from the ejector cooling point of view. (C) 2015 Elsevier Ltd. All rights reserved.