A new, reduced reaction mechanism for DME combustion in internal combustion engines is proposed. The new mechanism is based on a detailed DME mechanism suitable for low to high temperature ranges. The reduced model consists of 29 species and 66 reactions and contains a detailed H-2/CO mechanism and reduced C1-C2 chemistry. The reduced mechanism inherits the major reaction pathways of the detailed mechanism, which ensures its predictive capability when coupled into CFD simulations. The performance of the reduced mechanism was compared to simulation results of the detailed mechanism, ignition delay times from a shock tube and a rapid compression machine, and DME engine combustion data. Overall, the reduced mechanism shows a good balance between accuracy and computational efficiency necessary for use in combustion system design applications. (C) 2015 Elsevier Ltd. All rights reserved.