In this work, gamma-Al2O3 nanoparticles with mean diameter of 10nm are dispersed in deionized water with four nanoparticle volume concentrations of 0.25, 0.5, 0.75, and 1%. The effect of gamma-Al2O3/water nanofluids on the heat transfer enhancement of heat exchangers is investigated under turbulent regime for four different volumetric flow rates of 150, 200, 250, and 300 L/h. The experimental results showed that the convective heat transfer is increased by increasing particles volume fraction as well as flow rate. The maximum enhancement obtained in Nusselt number and heat transfer coefficient was 20 and 22.8%, respectively, at Reynolds number of 6026 and particle volume fraction of 1%. The experimental Nusselt numbers of nanofluids showed good agreement with the available empirical correlation at particle volume fractions of 0.25 and 0.5%. An empirical correlation is obtained to estimate the Nusselt number of nanofluid under the conditions of this work.