Pt/Al2O3 catalysts were used to deoxygenate m-cresol, which was used as a bio-oil model compound. The catalysts were characterized by XRD, TEM, XPS, hydrogen chemisorption, and BET surface analyses. The coke deposits on spent catalysts were analyzed by TPO. In this work, the catalysts deactivation and regeneration were addressed. Deactivation was caused by carbonaceous deposits formed mainly by cresol condensation products, in a parallel-type coke formation mechanism. The amount of carbon formed on the catalyst strongly depends on the metal/acid functions ratio. The gas phase reaction was carried out in a fixed bed reactor in the presence of H-2 at 300 degrees C and atmospheric pressure. The regeneration by coke removal using hydrogen or air was addressed. It was found that treatments in air at mild temperature led to the recovery of the catalytic activity, while the effectiveness of the treatment with H-2 strongly depends on the temperature, not being possible to recover the activity at 400 and 500 degrees C, while at 450 degrees C the catalyst was regenerated. This is because at the higher temperature, the coke left on the support had higher toxicity. The influence of platinum loading on activity and selectivity was also studied, and it was concluded that the selectivity to the desired deoxygenated product can be regulated by changing the metal content on the catalyst. The metal/acid sites ratio plays a key role in the coke deposition rate.