Phenolic compounds are widely used in chemical industrial applications. The traditional method of extracting phenolic compounds, which uses strong alkaline and acid, is harmful to the environment. In this research, amide and its homologues were developed as new extraction agents. They could form deep eutectic solvent (DES) with phenols, and this DES was immiscible with oil. Formation mechanism of the DES was investigated using a Fourier transform infrared spectrometer (FT-IR). A hydrogen bond (H-bond) between acylamino and phenolic hydroxyl groups was observed. Different experimental conditions, such as different substituents of amide compounds, reaction temperature, reaction time, and mole ratio of extraction agent to phenols were studied. The influence rules of different experimental conditions were obtained, and so did the optimized conditions. The extraction agent was recycled through back extraction and exhibited good recycling properity and high extraction efficiency. Based on above experimental results, a separation process was proposed.