IrO2 is one of the most active water oxidant catalysis for the oxygen evolution anode owing to its chemical stability and outstanding catalytic activities, however iridium (Ir) is also one of the rarest metals in the world. In this report, a novel highly active nanostructured IrO2/Ti anode for oxygen evolution reaction (OER) was fabricated by depositing IrO2 nanoparticles onto Ti nanotube substrates. This nanostructured IrO2/Ti anode exhibits comparable oxygen evolution catalytic activities as the traditional IrO2/Ti dimensional stable anode with only 1% iridium consumption of the traditional method. This nanostructured IrO2/Ti anode would be a promising candidate method for fabricating high effective IrO2/Ti anode with low Ir consumption. Copyright (C) 2015, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.