This paper aims to present a thermo-economic approach for methanol production comparing different renewable energy sources. In this study, the methanol is produced from the CO2 hydrogenation in a pressurized reactor; two different plant configurations are analyzed: in the first carbon dioxide is obtained from biogas upgrade, while in the second one CO2 is acquired from external sources. Carbon dioxide is mixed with hydrogen and then the gas is sent into the reactor for methanol synthesis. Hydrogen is produced by an alkaline pressurized electrolyzer (1 MW, 30 bar) fed by time-dependent electrical energy produced by renewable plants (hydroelectric, wind or photovoltaic), when available; in the remaining periods, electricity is purchased by the national grid. Since the available electrical energy from the different renewable sources is not constant throughout the year, a time-dependent hierarchical thermo-economic analysis is performed in order to investigate the best plant configuration. The analyses are performed with the W-ECoMP simulation tool (developed by the authors' research group) considering different costs of electricity and different methanol selling prices taking into account the future market forecast. The results for the two plant lay-outs are compared from energetic, economic and environmental point of view for the different renewable energy sources to evaluate the best solution in the Italian scenario. Copyright (C) 2015, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.