The aim of this study was to evaluate the shear bond strength (SBS) of orthodontic molar tubes bonded to amalgam restorations and enamel with four different area ratios, with and without the use of various metal primers. One hundred and fifty-six sound lower first molars were divided into five groups; control group (CG;n=12) then divided into three subgroups: A, B, and C. Class V buccal amalgam restorations consisting of 25%(G1), 50%(G2), 75%(G3), and 100%(G4) of the basal areas of the molar tubes. Transbond XT Primer (TXTP;subgroup A), Alloy Primer (AP;subgroup B) and Reliance Metal Primer (RMP;subgroup C) (n=12). Transbond XT was used as an adhesive material in all groups. Thermocycling was as 5-55 degrees C, 1000 cycles. Data were analysed by one-way ANOVA and post hoc least significant difference tests (p<0.05). Bond failure sites were classified using a modified Adhesive Remnant Index (ARI) system. SBS did not differ significantly among the three intermediate adhesives in subgroups of groups 1, 2, or 3 (p>0.05); however, SBS was significantly higher in groups 4B and 4C than in group 4A (p<0.05). Mean SBSs of groups 1 and 2 were significantly higher than others (p<0.05). Mean SBS of group 3 was higher than that of group 4, but lower than that of the other groups. For ARI, significant relationships between CG and the intermediate adhesive groups were found (p<0.05). Application of metal primers, such as AP or RMP, to sandblasted amalgam adjacent to etched enamel (25, 50, and 75%) did not improve bond strength significantly compared with the application of TXTP to amalgam and enamel.