Finding of thiosulfate pathway for synthesis of organic sulfur compounds in Saccharomyces cerevisiae and improvement of ethanol production

Funahashi E; Saiki K; Honda K; Sugiura Y; Kawano Y; Ohtsu I; Watanabe D; Wakabayashi Y; Abe T; Nakanishi T; Suematsu M; Takagi H

Journal of Bioscience and Bioengineering, Vol.120, No.6, 666-669, 2015

DOI10.1016/j.jbiosc.2015.04.011 Export Citation

Finding of thiosulfate pathway for synthesis of organic sulfur compounds in Saccharomyces cerevisiae and improvement of ethanol production

Funahashi E, Saiki K, Honda K, Sugiura Y, Kawano Y, Ohtsu I, Watanabe D, Wakabayashi Y, Abe T, Nakanishi T, Suematsu M, Takagi H

We found that Saccharomyces cerevisiae utilizes thiosulfate as a sole sulfur source. The energetically-favored thiosulfate rather than sulfate as sulfur sources is also more effective for improving growth and ethanol-production rate in S. cerevisiae due to high levels of intracellular NADPH during thiosulfate utilization. (c) 2015, The Society for Biotechnology, Japan. All rights reserved.

Keywords:Saccharomyces cerevisiae;Thiosulfate assimilation;Ethanol production;Pentose phoshate pathway;Sulfur metabolism;Sulfur metabolome