The solubility of (2S)-pyrrolidine-2-carboxylic acid in pure alcohols (methanol, ethanol, isopropyl alcohol, and butan-1-ol) and the aqueous alcohols (methanol, ethanol, and isopropyl alcohol) mixtures was measured by a dynamic method via a laser monitoring technique. The solubility in the pure alcohols follows the order methanol > ethanol > butan-1-ol > isopropyl alcohol. In the binary mixtures, the solubility decreases with the increase of alcohol concentration. The experimental solubility was fitted by the modified Apelblat equation, combined nearly ideal binary solvent/Redlich-Kister (CNIBS/R-K) model, and Van't Hoff equation. The dissolution is endothermic and the dissolution driving force converts from enthalpy-driven to entropy-driven.