For the first time the extract of the plant of Euphorbia granulate was used to green synthesis of Pd nanoparticles (NPs) as a heterogeneous catalyst for the phosphine-free Suzuki-Miyaura coupling reaction at room temperature. This method is a facile and eco-friendly way in organic synthesis using the plant extract as biomedia, bioreductant and capping ligand which considerably stabilizes the surface of Pd NPs. The presence of flavonoid and phenolics acids in the extract could be responsible for the reduction of Pd2+ ions and formation of the corresponding Pd NPs. (C) 2015 Elsevier Inc. All rights reserved.