The Donnan Steric Pure Model with dielectric exclusion (DSPM-DE) is implemented over flat sheer and spiral-wound leaves to develop a comprehensive model for nanoffltration modules. This model allows the user to gain insight into the physics of the nanofiltration process by allowing one to adjust and investigate effects of membrane charge, pore radius, and other membrane characteristics. The study shows how operating conditions such as teed flow rate and pressure affect the recovery ratio and solute rejection across the membrane. A comparison is made between the results for the flat-sheet and spiral-wound configurations. The comparison showed that for the spiral-wound leaf, the maximum values of transmembrane pressure, flux and velocity occur at the teed entrance (near the permeate exit), and the lowest value of these quantities are at the diametrically opposite corner. This is in contrast to the flat-sheet leaf, where all the quantities vary only in the feed flow direction. However it is found that the extent of variation of these quantities along the permeate flow direction in the spiral-wound membrane is negligibly small in most cases. Also, for identical geometries and operating conditions, the flat-sheet and spiral-wound configurations give similar results. Thus the computationally expensive and complex spiral-wound model can be replaced by the flat-sheet model for a variety of purposes. In addition, the model was utilized to predict the performance of a seawater nanofiltration system which has been validated with the data obtained from a large-scale seawater desalination plant, thereby establishing a reliable model for desalination using nanoffltration. (C) 2015 Elsevier B.V. All rights reserved.