Mesoporous TiO2 with well-distributed RuO2 catalysts is considered in this paper as a carbon-free cathode material replacement. Benefiting from the highly-porous TiO2 support structure and high catalytic activity of RuO2, the Li-O-2 cells with composite RuO2/mesoporous TiO2 cathodes show low charge potentials with a high cell capacity. The stability of the TiO2 materials was verified by investigating stable cell performance as well as through structural and chemical characterization via X-ray diffraction and Xray photoelectron spectroscopy. This study demonstrates the possibility of achieving high energy at the cell level, free of carbon instability. (C) 2015 Elsevier B.V. All rights reserved.