An experimental 2(2) design with center point in three replicates was used to investigate the influential factors, such as pressure and temperature, in the extraction of oil from Penile frutescens using compressed n-propane as a solvent, and to compare with the classical Soxhlet method. The experiments were performed in the temperature range of 40-80 degrees C and pressure of 8-16 MPa at a constant flow rate of 1.0 cm(3)/min n-propane. All the conditions applied in the extraction using compressed n-propane provided good results and similar yields. However, the highest yield of extraction was obtained by the Soxhlet classical methodology. Moreover, higher induction times and concentrations of tocopherol and phytosterol were determined in oils resulting from compressed n-propane extraction. The Sovova mathematical model indicated a good fit for all conditions investigated. (C) 2015 Elsevier B.V. All rights reserved.