화학공학소재연구정보센터
Journal of the American Chemical Society, Vol.137, No.34, 10958-10961, 2015
Stereospecific Coupling of Boronic Esters with N-Heteroaromatic Compounds
A protocol for the stereospecific coupling of chiral secondary and tertiary boronic esters with lithiated N-heteroaromatics is described. The process involves initial boronate complex formation followed by addition of Troc-Cl, which activates the nitrogen and induces 1,2-migration. Oxidative workup furnishes the coupled product with >98% es.