Journal of the American Chemical Society, Vol.137, No.28, 8900-8903, 2015
Direct Generation of Triketide Stereopolyads via Merged Redox-Construction Events: Total Synthesis of (+)-Zincophorin Methyl Ester
(+)-Zincophorin methyl ester is prepared in 13 steps (longest linear sequence), A bidirectional redox-triggered double anti-crotylation of 2-methyl-1,3-propane diol directly assembles the triketide stereopolyad spanning C4-C12, significantly.,enhancing step economy and enabling construction of (+)-Zincophorin methyl ester in nearly half the steps previously required.