We report a strategy of Combining a Bronsted acid metal organic framework (MOP) With Lewis acid centers to afford a Lewis acid@Bronsted acid:MOF with high catalytic activity, as exemplified, in the context of MIL-101Cr-SO3H.Al(III). Because of the synergy between the Bronsted acid framework and the Al(III) Lewis acid centers, MIL-101-Cr-SO3H-Al(III) demonstrates excellent catalytic performance in a series of fixed-bed reactions, outperforming two benchmark zeolite Catalysts (H-Beta and HMOR). Our work therefore not Only provides a new approach to achieve high catalytic activity in MOFs but also paves a way to develop MOFs as a new type of highly efficient heterogeneous catalysts for fixed-bed reactions.