In recent years, problems related to chemicals such as endocrine disrupters and dioxin have attracted attention, and the need for chemical substance management among chemical manufacturers has been recognized. Based on a case study, this paper proposes and instance model for the decision-making process in a company where the safety of a product is suspected. It was found that a company's decision-making is based on the requirements of stakeholders, legal regulations, company policy (environmental management) and future prediction (regulations and market trends).