This work summarises for the first time the authors' results in the field of lyotropic mesomorphism dealing with the study of disc-like compounds (benzene, scyllitol, benzenehexamine, triphenylene, phthalocyanine, triazacyclononane derivatives and dendrimers) in organic solvents. The authors answer a number of hey-questions, connected with induction/variation of lyotropic liquid crystal properties of above mentioned mesomorphic and non-mesomorphic materials. A comprehensive survey of the data is the basis for prediction of new lyotropic compositions with induction/variation of mesomorphic properties for disc- and lath-like hydrophobic compounds.