One of the most important quests in modern science is the ability to mimic DNA replication, this process provides opportunities to vastly improve current technology from data storage to fighting disease. How molecular processes govern DNA signalling is a key question to be answered for this endeavour to be achieved. One of the greatest difficulties with DNA manipulation has been to physically manipulate individual DNA molecules. In vivo there are a large variety of proteins present which are finely controlled by other proteins and signalling molecules to ensure DNA will coil when required and uncoil for replication when stimulated. Understanding the dynamics of motion of particles and molecules that participate in DNA processes is key to understanding and potentially mimicking these processes. In this review, we introduce the current knowledge with respect to molecular dynamics of motion and draw reference to DNA natural and artificial processes. We also discuss the motion mechanisms and how they might explain the efficiency of DNA signalling and replication processes. (C) 2015 Elsevier Ltd. All rights reserved.