The design and Cost-benefit analysis (CBA) of a novel anaerobic bioenergy plant is presented. This plant can digest various feed sources including animal-manure, vegetable-fruit wastes, poultry wastes, sugar molasses etc. The fixed dome multi-digestor system enables a continuous feed and flow mechanism. It is also equipped with a biogas purification, compression and storage system. This medium scale bioenergy plant is the first of its kind in Pakistan. It has a total installation cost of US$105,000 and annual operation and maintenance cost of US$23,400. The average energy production is 142,380 kWh per annum. With a current average energy cost of US$0.315 per kWh from all sources in Pakistan, the cost-benefit ratio is 1.2 at an internal rate of return (IRR) of 19.76%, and short payback period. (C) 2016 Elsevier Ltd. All rights reserved.