The enthalpies of L-proline dissolution in aqueous solution of N,N-dimethylformamide (DMF) with a mole-fraction of DMF from x(2) = (0-0.2) have been measured at 293.15-308.15 K. The results obtained have been used to calculate the standard enthalpies of solution (Delta H-sol degrees) and transfer (Delta H-tr degrees) of L-proline from water into mixtures as well as the enthalpy coefficients of pairwise interaction (h(xy)) of the solute with DMF in aqueous medium. The interconnection between enthalpy characteristics of L-proline dissolution (transfer) and the composition of (H2O + DMF) mixture and its temperature have been established. The resulting data have been compared with those obtained before for some amino acids with cyclic side-chain: L-phenylalanine and L-tryptophan in the same mixed solvent at 298.15 K has been made. (C) 2015 Elsevier B.V. All rights reserved.