The enthalpies of L-methionine dissolution in aqueous solution of acetonitrile, 1,4-dioxane, acetone, dimethylsulfoxide, formamide, N-methylformamide, N,N-dimethylformamide and N,N-dimethyl acet amide were determined by calorimetric method at 298.15K and organic solvent mole fractions up to x(2) similar to 0.35. The standard enthalpies of solution (Delta H-sol(o)) and transfer (Delta H-tr(o)) of L-methionine from water to a mixed solvent as well as the enthalpy coefficients of pairwise interactions (h(xy)) were calculated. The interrelation between enthalpy characteristics of L-methionine dissolution (transfer) and the composition of water-organic mixtures was determined. Contributions of the organic solvent properties (molar volume, cohesion energy density, polarity/polarizability, acidity and basicity) to the energy of pairwise interactions of L-methionine - organic solvent were estimated quantitatively by means of a modified Kamlet-Taft equation. Some characteristics of intermolecular interactions of L-methionine with the molecules of organic solvents were compared with the analogous characteristics of previously investigated amino acids. (C) 2015 Elsevier B.V. All rights reserved.