It has been demonstrated that the alarming increase in UV radiation on the ground and intensive or repeated sun expositions cause systemic effects that can be shown as alterations of the general defense mechanisms against free radicals, increase of red blood cells fragility or a systemic immunosuppression. This article is the first step in developing new cosmetics based on nanostructured complexes containing active principles extracted from animal (collagen) and vegetal (polyphenols) tissues, with sun protective and antioxidant activity. The antioxidant activity has been monitored by chemiluminescence, while the photo-protective capacity has been quantified by using diffuse reflectance spectroscopy (Sun Protection Factor).