In this study, a series of new blue phosphorescent iridium(III) complexes with ligands of (CF(3))(2)Meppy [(CF(3))(2)Meppy = 2-(3',5'-bis-trifluoromethylphenyl)-4-methylpyridine] were successfully synthesized and their photophysical properties were systematically investigated. To analyze color tuning effected by changing the ancillary ligands, we have measured UV-absorption and photoluminescence (PL) spectra and have theoretically calculated the iridium complexes with different ancillary ligands using computational methods. The maximum emission spectrum of Ir[(CF(3))(2)Meppy](2)(acac), Ir[(CF(3))(2)Meppy](2)(pic), Ir[(CF(3))(2)Meppy](2)(taz) and Ir[(CF(3))(2)Meppy](2)(N(4)) were 473.5, 472, 475 and 468 nm, respectively. However, the PL efficiency was not improved by changing the picolinate ligands with other ancillary ligands, such as triazolate or tetrazolate ions.