Series of ether-ester-substituted 1,4:3,6-dianhydrohexitols were synthesized and studied as chiral dopants to nematics as compositions with 4 '-pentyl-4-cyanobiphenyl. The most helical twisting power was found for bis-esters. Lesser values were found for mixed ether-esters with certain configuration. Other ethers and ether-esters revealed noticeably smaller values. Supramolecular peculiarities of such systems and their role in helical twisting are discussed.