Using a polyacrylamide gel method, a series of LaSrCo0.9B'O-0.1(4)(B'= Mn: Fe: Ni, Cu) mixed oxides were prepared and their catalytic activity was studied with CO and C3H8 oxidations as a testing reaction. The results show that the specific effects of B' ions on CO and C3H8 oxidations depend on their category. In comparison to LaSrCoO4 catalyst, the activity of LaSrCo0.9Ni0.1O4 catalyst for GO and C3H8 oxidations is higher, while only lower activity is obtained for Mn, Fe or Cu-doped catalysts. The information derived from TPD, XRD and iodometry experiments shows that the increase in oxidation activity of LaSrCo0.9Ni0.1O4 catalyst towards CO and C3H8 oxidation can be related to the increases in O-2-adsorption quantity, CO2-desorption quantity, oxygen vacancies and lattice distortion due to the adulteration of nickel. Further investigation shows that the apparent activation energy of LaSrCo0.9Ni0.1O4 towards GO oxidation is lower than that of LaSrCoO4.