Turkish Journal of Chemistry, Vol.34, No.3, 411-416, 2010
An efficient one-pot synthesis of dihydropyrimidinones catalyzed by zirconium hydrogen phosphate under solvent-free conditions
A simple, efficient, and practical procedure for the Biginelli reaction using zirconium hydrogen phosphate [Zr(H(2)PO(4))(2)] as a novel solid acid catalyst is described under solvent-free conditions in high yields. The catalyst exhibited remarkable reactivity and it is reusable.
Keywords:Biginelli reaction;solvent-free;zirconium hydrogen phosphate;dihydropyrimidinones;recyclable catalyst