Electrical energy offers numerous benefits for performing synthesis, including increased reaction rates, enhanced yields, and cleaner chemistries. 5-Substituted-2-amino-1,3,4-oxadiazoles were synthesized directly from the semicarbazone at a platinum electrode under controlled potential electrolysis in an undivided cell assembly in acetonitrile. The compounds were screened for antibacterial and antifungal activity against Staphylococcus aureus, Klebsiella pneumoniae, Pellicularia salmonicolor, and Macrophomina phaseolina.