Turkish Journal of Chemistry, Vol.35, No.1, 121-130, 2011
Synthesis and evaluation of the analgesic activity of some new isoxazolo[4,5-d]pyridazin-4(5H)-one derivatives
Some isoxazolo[4,5-d] pyridazin4(5H)-one derivatives were synthesized and tested for their analgesic activity. The analgesic activities of the compounds were determined by hot-plate and acetic acid writhing tests using morphine and diclofenac as references. Compounds 4a, 4f, 4g, and 4i (25 mg/kg) showed analgesic profiles similar to that of morphine (5 mg/kg).