Turkish Journal of Chemistry, Vol.36, No.3, 467-476, 2012
Silica nanoparticles as a high efficient catalyst for the one-pot synthesis of 3-oxo-3-phenylpropanamid derivatives from isocyanides, phenylacetaldehyde and secondary amines
Reaction of an isocyanide with an iminium ion intermediate, formed by reaction between 2-oxo-2-phenylacetaldehyde and a secondary amine in the presence of silica nanoparticles, proceeds smoothly at room temperature to afford ketoamide derivatives in high yields.
Keywords:Silica nanoparticles;multicomponent reaction;isocyanide;2-oxo-2-phenylacetaldehyde;secondary amine;iminium ion