Turkish Journal of Chemistry, Vol.38, No.2, 288-296, 2014
Calixpenams: synthesis, characterization, and biological evaluation of penicillins V and X clustered by calixarene scaffold
Four 6-aminopenicillanic acid moieties were grafted at either rim of calix[ 4] arene, giving 2 novel generations of penicillin, which were named calixpenam. Antibiotic tests showed that they have amplified activity with respect to the corresponding penams against 3 gram-positive nonpenicillinase-producing strains of Streptococcus