The aim of this study was to evaluate the possibilities of replacing the energetic crop (EC) in the feed-in mixture (ingestate) with the organic fraction of municipal solid waste (OFMSW), in an anaerobic full-scale plant comprising four continuous stirred tank reactors (CSTRs) along with post-digester. A fullscale plant performing anaerobic digestion (AD) was monitored for 8 months, and during this period, 55 samples of both ingestates and cligestates from the digesters (hydraulic retention time, HRT, of 40 d) and post-digester (HRT of 10 d) were collected before and after OFMSW introduction and analyzed for both biological and chemical parameters. The result obtained showed that substitution of EC (Mix A) with OFMSW (Mix B) did not lead to substantial modification of the feed-in mixture and AD process. Mixtures A and B gave similar specific biogas (i.e., 585 +/- 198 m(3) Mg TS(-1) and 567 +/- 162 m(3) Mg TS(-1) for Mix A and B, respectively), showing high process performances, i.e.. 95% of the total anaerobic biogas producible was produced during the AD processes (HRT of 50 d). The digestates produced showed similar characteristics and can be potentially used in agriculture. The OFMSW offers new opportunities for farmers to produce renewable energy, by lowering the cost of the biomass and producing a useful fertilizer/amendment product. (C) 2009 Elsevier Ltd. All rights reserved.