Organic-inorganic heterostructures are an emerging topic that is very interesting for optoelectronics. Here, non-conventional p-n junctions are investigated using organic rubrene single crystal and 2D MoS2 as the p-and n-type semiconducting materials, respectively. The current-rectifying behavior is clearly observed in the junction device. The rectifi cation ratio can be electrically tuned by the gate voltage due to the 2D nature of the heterostructure. The devices also show good photoresponse properties with a photoresponsivity of approximate to 500 mA W-1 and a fast response time. These fi ndings suggest a new route to facilitate the design of nanoelectronic and optoelectronic devices based on layered inorganics and organics.