Liquid-phase sensing of various organic solvents is performed for the first time, using a solvent-resistant organic-transistor platform. Sensors composed of a cross-linked poly(3-hexylthiophene) (P3HT)-azide co-polymer and a calixarene derivative exhibit highly sensitive and selective sensing behavior, owing to the selective binding effects of the liquid analytes with the calixarene-functionalized P3HT-azide, extending the range of their use in practical applications.