Partial polymerization during photolithography is precisely controlled to obtain a partially cured (PCP) layer on the formed 3D microstructures. Upon plasma treatment, a 3D surface with morphologically tunable and spatially controllable wrinkles is obtained. The fabrication process is characterized and its ability to make various wrinkled microstructures is demonstrated. Experiments show cells can sense 3D wrinkled microstructures, attach, and bridge between them.